Genetic influence on clinical and pathologic characteristics in Alzheimer's Lead Investigator: Jee Hoon Roh Institution : Dept. of Neurology, Asan Medical Center E-Mail : alzheimer@naver.com Proposal ID : 857 Proposal Description: There exist potential racial differences in genetic risk factors for Alzheimer's disease (AD). For example, subcortical ischemic changes have been noted to be more common in AD patients in Asian countries. In this study, by comparing domestic and NACC dataset, we are going to investigate whether the effect of genetic influence on clinical and pathologic characteristics of AD spectrum disorders can be different in Asians and Caucasians.